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Identification of the potential molecular mechanism and driving mutations in the pathogenesis of familial intestinal gastric cancer by whole exome sequencing.

Oncology reports - 1 Oct 2018

Chen Haixiang, Wang Juan, Zhuang Yi, Wu Hao

Abstract excerpt

The genetic alterations in familial intestinal gastric cancer (FIGC) have not been clearly understood. Aiming to explore the molecular basis and the driving mutations underlying the pathogenesis of FIGC, we performed exome sequencing of the blood samples of the members of an extended family with FIGC. The differences in mutation patterns between family members with gastric cancer and controls were analysed and...

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PMID: 30106433
DOI: 10.3892/or.2018.6613

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ESR1

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