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Article

Germline genetic variants were interactively associated with somatic alterations in gastric cancer.

Cancer medicine - 1 Aug 2018

Zhang Xu, Wang Yuzhuo, Tian Tian, Zhou Gangqiao, Jin Guangfu

Abstract excerpt

Genome-wide association studies have identified several germline variants in gastric cancer. Meanwhile, sequencing studies have characterized extensive somatic alterations that arise during gastric carcinogenesis. However, the relationship between the germline variants and somatic alterations is still unclear in gastric cancer. A total of 11 susceptibility loci and 276 driver genes of gastric cancer were...

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PMID: 29923336
DOI: 10.1002/cam4.1612
PMCID: PMC6089170

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RFC4

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