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How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia: can we learn from other noncoding repeat expansion disorders?

Current opinion in neurology - 1 Dec 2012

van Blitterswijk Marka, DeJesus-Hernandez Mariely, Rademakers Rosa

Abstract excerpt

PURPOSE OF REVIEW: The aim of this review is to describe disease mechanisms by which chromosome 9 open reading frame 72 (C9ORF72) repeat expansions could lead to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) and to discuss these diseases in relation to other noncoding repeat expansion disorders. RECENT FINDINGS: ALS and FTD are complex neurodegenerative disorders with a considerable...

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Identifiers

PMID: 23160421
DOI: 10.1097/WCO.0b013e32835a3efb
PMCID: PMC3923493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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