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Article

Involvement of dopamine receptor in the actions of non-psychoactive phytocannabinoids.

Biochemical and biophysical research communications - 17 Dec 2020

Shrader Sarah H, Tong Yong-Guang, Duff Maxwell B, Freedman Jonathan H, Song Zhao-Hui

Abstract excerpt

Nematode Caenorhabditis elegans (C. elegans) exhibited a vigorous swimming behavior in liquid medium. Addition of dopamine inhibited the swimming behavior, causing paralysis in 65% of wild-type nematodes. Interestingly, phytocannabinoids cannabidiol (CBD) or cannabidivarin (CBDV), caused paralysis in 40% of the animals. Knockout of DOP-3, the dopamine D2-like receptor critical for locomotor behavior, eliminated...

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Identifiers

PMID: 33097185
DOI: 10.1016/j.bbrc.2020.10.021
PMCID: PMC7744432

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