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Article

Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex.

Scientific reports - 29 Jan 2021

Tizzano Barbara, Dallenga Tobias K, Utpatel Christian, Behrends Jochen, Homolka Susanne, Kohl Thomas A, Niemann Stefan

Abstract excerpt

While persistence in a dormant state is crucial for the life cycle of Mycobacterium tuberculosis, no investigation regarding dormancy survival of different strains across different lineages was performed so far. We analyzed responses to oxygen starvation and recovery in terms of growth, metabolism, and transcription. All different strains belonging to the Euro-American lineage (L4) showed similar survival and...

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PMID: 33514768
DOI: 10.1038/s41598-021-81223-6
PMCID: PMC7846770

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