Article
Thalamic atrophy in patients with pure hereditary spastic paraplegia type 4.
Journal of neurology - 1 Jul 2021
Navas-Sánchez Francisco J, Fernández-Pena Alberto, Martín de Blas Daniel, Alemán-Gómez Yasser, Marcos-Vidal Luís, Guzmán-de-Villoria Juan A, Fernández-García Pilar, Romero Julia, Catalina Irene, Lillo Laura, Muñoz-Blanco José L, Ordoñez-Ugalde Andrés, Quintáns Beatriz, Pardo Julio, Sobrido María-Jesús, Carmona Susanna, Grandas Francisco, Desco Manuel
Abstract excerpt
SPG4 is an autosomal dominant pure form of hereditary spastic paraplegia (HSP) caused by mutations in the SPAST gene. HSP is considered an upper motor neuron disorder characterized by progressive spasticity and weakness of the lower limbs caused by degeneration of the corticospinal tract. In other neurodegenerative motor disorders, the thalamus and basal ganglia are affected, with a considerable impact on disease...
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