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Article

Microstructural integrity of cerebral fiber tracts in hereditary spastic paraparesis with SPG11 mutation.

AJNR. American journal of neuroradiology - 1 May 2013

Pan M-K, Huang S-C, Lo Y-C, Yang Chih-Chao, Cheng T-W, Yang Chi-Cheng, Hua M-S, Lee M-J, Tseng W-Y I

Abstract excerpt

BACKGROUND AND PURPOSE: ARHSP-TCC is characterized by progressive leg spasticity, ataxia, and cognitive dysfunction. Although mutations in the human SPG11 gene were identified as responsible for ARHSP-TCC, the cerebral fiber integrity has not been assessed systemically. The objective of this study was to assess cerebral fiber integrity and its clinical significance in patients with ARHSP-TCC. MATERIALS AND...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23221952
DOI: 10.3174/ajnr.A3330
PMCID: PMC7964653

Genes

SPG11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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