Article
Principal component analysis of cerebellar shape on MRI separates SCA types 2 and 6 into two archetypal modes of degeneration.
Cerebellum (London, England) - 1 Dec 2012
Jung Brian C, Choi Soo I, Du Annie X, Cuzzocreo Jennifer L, Geng Zhuo Z, Ying Howard S, Perlman Susan L, Toga Arthur W, Prince Jerry L, Ying Sarah H
Abstract excerpt
Although "cerebellar ataxia" is often used in reference to a disease process, presumably there are different underlying pathogenetic mechanisms for different subtypes. Indeed, spinocerebellar ataxia (SCA) types 2 and 6 demonstrate complementary phenotypes, thus predicting a different anatomic pattern of degeneration. Here, we show that an unsupervised classification method, based on principal component analysis...
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