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Article

Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder.

Scientific reports - 27 Jan 2021

Moreno-Alcázar Ana, Ramos-Quiroga Josep A, Ribases Marta, Sánchez-Mora Cristina, Palomar Gloria, Bosch Rosa, Salavert Josep, Fortea Lydia, Monté-Rubio Gemma C, Canales-Rodríguez Erick J, Milham Michael P, Castellanos F Xavier, Casas Miquel, Pomarol-Clotet Edith, Radua Joaquim

Abstract excerpt

Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 (ADGRL3; formerly latrophilin 3, LPHN3) is associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Conversely, no studies have investigated the anatomical or functional brain substrates of ADGRL3 risk variants. We examined here whether individuals with different ADGRL3 haplotypes, including both patients with...

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Identifiers

PMID: 33504901
DOI: 10.1038/s41598-021-81915-z
PMCID: PMC7840726

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