Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile.

doi:10.1111/dme.14531

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Article

Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile.

Diabetic medicine : a journal of the British Diabetic Association - 1 Sept 2021

Heald Adrian H, Martin Susan, Fachim Helene, Green Harry D, Young Katherine G, Malipatil Nagaraj, Siddals Kirk, Cortes Gabriela, Tyrrell Jessica, Wood Andrew R, Beaumont Robin N, Frayling Timothy M, Donn Rachelle, Narayanan Ram Prakash, Ollier William, Gibson Martin, Yaghootkar Hanieh

Abstract excerpt

AIMS: Change in weight, HbA1c , lipids, blood pressure and cardiometabolic events over time is variable in individuals with type 2 diabetes. We hypothesised that people with a genetic predisposition to a more favourable adiposity distribution could have a less severe clinical course/progression. METHODS: We involved people with type 2 diabetes from two UK-based cohorts: 11,914 individuals with GP follow-up data...

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PMID: 33501652
DOI: 10.1111/dme.14531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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