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Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies

26 Jan 2021

Abstract excerpt

PURPOSE: To characterize the genetic architecture of left ventricular noncompaction (LVNC) and investigate the extent to which it may represent a distinct pathology or a secondary phenotype associated with other cardiac diseases. METHODS: We performed rare variant association analysis with 840 LVNC cases and 125,748 gnomAD population controls, and compared results to similar analyses on dilated cardiomyopathy...

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PMID: 33500567
DOI: 10.1038/s41436-020-01049-x

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