Article
Promoter hypermethylation of ARID1A gene is responsible for its low mRNA expression in many invasive breast cancers.
PloS one - 1 Jan 2013
Zhang Xianyu, Sun Qian, Shan Ming, Niu Ming, Liu Tong, Xia Bingshu, Liang Xiaoshuan, Wei Wei, Sun Shanshan, Zhang Youxue, Liu Xiaolong Sean, Song Qingbin, Yang Yanmei, Ma Yuyan, Liu Yang, Yang Long, Ren Yanlv, Zhang Guoqiang, Pang Da
Abstract excerpt
ARID1A (AT-rich interactive domain 1A) has recently been identified as a tumor suppressor gene. Its mRNA expression is significantly low in many breast cancers; this is often associated with more aggressive phenotypes. However, the underlying molecular mechanism for its low expression has not been fully understood. This study was undertaken to evaluate the contribution of gene copy number variation, mutations,...
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