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Article

Response of Pluripotent Stem Cells to Environmental Stress and Its Application for Directed Differentiation

23 Jan 2021

Abstract excerpt

Pluripotent stem cells have unique characteristics compared to somatic cells. In this review, we summarize the response to environmental stresses (hypoxic, oxidative, thermal, and mechanical stresses) in embryonic stem cells (ESCs) and their applications in the differentiation methods directed to specific lineages. Those stresses lead to activation of each specific transcription factor followed by the induction...

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PMID: 33498611
DOI: 10.3390/biology10020084

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