Article
Efficient detection and post-surgical monitoring of colon cancer with a multi-marker DNA methylation liquid biopsy.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2021
Jin Shengnan, Zhu Dewen, Shao Fanggui, Chen Shiliang, Guo Ying, Li Kuan, Wang Yourong, Ding Rongxiu, Gao Lingjia, Ma Wen, Lu Tong, Li Dandan, Zhang Zhengzheng, Cai Suili, Liang Xue, Song Huayu, Ji Ling, Li Jinlei, Zheng Zhihai, Jiang Feizhao, Wu Xiaoli, Luan Ju, Zhang Huxiang, Yang Zhengquan, Cantor Charles R, Xu Chang, Ding Chunming
Abstract excerpt
Multiplex assays, involving the simultaneous use of multiple circulating tumor DNA (ctDNA) markers, can improve the performance of liquid biopsies so that they are highly predictive of cancer recurrence. We have developed a single-tube methylation-specific quantitative PCR assay (mqMSP) that uses 10 different methylation markers and is capable of quantitative analysis of plasma samples with as little as 0.05%...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.