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Quantification method of ctDNA using cell-free DNA methylation profile for noninvasive screening and monitoring of colon cancer

19 Jul 2024

Abstract excerpt

BACKGROUND: Colon cancer ranks as the second most lethal form of cancer globally. In recent years, there has been active investigation into using the methylation profile of circulating tumor DNA (ctDNA), derived from blood, as a promising indicator for diagnosing and monitoring colon cancer. RESULTS: We propose a liquid biopsy-based epigenetic method developed by utilizing 49 patients and 260 healthy controls...

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PMID: 39030645
DOI: 10.1186/s13148-024-01708-9

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