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Targeted eicosanoids profiling reveals a prostaglandin reprogramming in breast Cancer by microRNA-155

25 Jan 2021

Abstract excerpt

BACKGROUND: Prostaglandin is one of the key metabolites for inflammation-related carcinogenesis. Despite the microRNA-155 is implicated in various types of cancers, it's function in prostaglandin metabolism is largely unknown. METHODS: A targeted profiling of eicosanoids including prostaglandin, leukotriene and thromboxanes was performed in miR-155 deficient breast tumors and cancer cells. The molecular mechanism...

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PMID: 33494773
DOI: 10.1186/s13046-021-01839-4

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