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Article

Notch3 Deficiency Attenuates Pulmonary Fibrosis and Impedes Lung-Function Decline.

American journal of respiratory cell and molecular biology - 1 Apr 2021

Vera Laura, Garcia-Olloqui Paula, Petri Eva, Viñado Ana Cristina, Valera Pablo S, Blasco-Iturri Zuriñe, Calvo Isabel A, Cenzano Itziar, Ruppert Clemens, Zulueta Javier J, Prosper Felipe, Saez Borja, Pardo-Saganta Ana

Abstract excerpt

Fibroblast activation includes differentiation to myofibroblasts and is a key feature of organ fibrosis. The Notch pathway has been involved in myofibroblast differentiation in several tissues, including the lung. Here, we identify a subset of collagen-expressing cells in the lung that exhibit Notch3 activity at homeostasis. After injury, this activation increases, being found in αSMA-expressing myofibroblasts in...

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Identifiers

PMID: 33493092
DOI: 10.1165/rcmb.2020-0516OC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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