Systemic autoinflammatory diseases

Abstract excerpt

Systemic autoinflammatory diseases (SAIDs) are a growing group of disorders caused by a dysregulation of the innate immune system leading to episodes of systemic inflammation. In 1997, MEFV was the first gene identified as disease causing for Familial Mediterranean Fever, the most common hereditary SAID. In most cases, autoinflammatory diseases have a strong genetic background with mutations in single genes....

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• Autoimmune and Inflammatory Disorders Research
• IL-33, ST2, and ILC Pathways
• Inflammasome and immune disorders