Article
TDP-43 plasma levels are higher in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 Sept 2012
Verstraete Esther, Kuiperij H Bea, van Blitterswijk Marka M, Veldink Jan H, Schelhaas H Jurgen, van den Berg Leonard H, Verbeek Marcel M
Abstract excerpt
Our objective was to investigate TDP-43 plasma levels in patients with amyotrophic lateral sclerosis (ALS). TDP-43 has been identified as a major component of protein inclusions in the brain of patients with ALS; mutations in the corresponding gene (TARDBP) have also been identified. Although increased TDP-43 levels have been reported in the cerebrospinal fluid, plasma levels have not yet been assessed in...
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