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Article

Down regulation of U2AF1 promotes ARV7 splicing and prostate cancer progression.

Biochemical and biophysical research communications - 19 Feb 2021

Cao Hongwen, Wang Dan, Gao Renjie, Chen Lei, Feng Yigeng

Abstract excerpt

The present study aims to investigate the roles of U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) in the resistance to anti-androgen treatment in prostate cancer and its underlying mechanism. U2AF1 and androgen receptor variant 7 (ARV7) knockdown and overexpression were introduced in PC3 and DU145 cells. In addition, a bicalutamide-resistant PC3 (PC3 BR) cell line was also constructed. Cell count, MTT and soft...

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Identifiers

PMID: 33477033
DOI: 10.1016/j.bbrc.2020.12.111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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