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Article

p53 affects epigenetic signature on SOCS1 promoter in response to TLR4 inhibition.

Cytokine - 1 Apr 2021

Sheikh Touseef, Sen Ellora

Abstract excerpt

Suppressor of cytokine signaling (SOCS1) functions as a negative regulator of toll-like receptor (TLR) induced inflammatory signaling. As silencing of SOCS1 is concomitant with elevated TLR4 levels in glioblastoma, we investigated the effect of TLR4 inhibition on SOCS1 expression. Pharmacological inhibition of TLR4 signaling by TAK242 or its siRNA-mediated knockdown in p53 mutant or wild-type glioma cells...

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Share to Epigenesis, Genetic
Share to Gene Expression Regulation, Neoplastic
Share to Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Small Interfering

Share to Suppressor of Cytokine Signaling 1 Protein

Share to Toll-Like Receptor 4

Share to Transcription, Genetic

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 33476981
DOI: 10.1016/j.cyto.2020.155418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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