Article
Sleep phenotype of individuals with autism spectrum disorder bearing mutations in the PER2 circadian rhythm gene.
American journal of medical genetics. Part A - 1 Apr 2021
Hoang Ny, Yuen Ryan K C, Howe Jennifer, Drmic Irene, Ambrozewicz Patricia, Russell Carolyn, Vorstman Jacob, Weiss Shelly K, Anagnostou Evdokia, Malow Beth A, Scherer Stephen W
Abstract excerpt
The Per family of genes functions as a primary circadian rhythm maintenance in the brain. Mutations in PER2 are associated with familial advanced sleep-phase syndrome 1 (FASPS1), and recently suggested in delayed sleep phase syndrome and idiopathic hypersomnia. The detection of PER2 variants in individuals with autism spectrum disorder (ASD) and without reported sleep disorders, has suggested a role of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.