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Article

Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients.

Brain & development - 1 Jan 2016

Yang Zhiliang, Matsumoto Ayumi, Nakayama Kazuhiro, Jimbo Eriko F, Kojima Karin, Nagata Koh-ichi, Iwamoto Sadahiko, Yamagata Takanori

Abstract excerpt

BACKGROUND: The genetic background of autism spectrum disorder (ASD) is considered a multi-genetic disorder with high heritability. Autistic children present with a higher prevalence of sleep disorders than has been observed in children with normal development. Some circadian-relevant genes have been associated with ASD (e.g., PER1, PER2, NPAS2, MTNR1A, and MTNR1B). METHODS: We analyzed 28 ASD patients (14 with...

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Source

Identifiers

PMID: 25957987
DOI: 10.1016/j.braindev.2015.04.006

Genes

PER2
PER3
TIMELESS
CLOCK
PER1
NPAS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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