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Article

Genetic alterations and functional networks of m6A RNA methylation regulators in pancreatic cancer based on data mining

30 Jul 2021

Abstract excerpt

BACKGROUND: Pancreatic cancer is a fatal malignancy of the digestive system and the 5-year survival rate remains low. Therefore, new molecular therapeutic targets are required to improve treatments, prognosis, and the survival of patients. N6-methyladenosine (m6A) is the most prevalent reversible methylation in mammalian messenger RNA (mRNA) and has critical roles in the tumorigenesis and metastasis of various...

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PMID: 34330301
DOI: 10.1186/s12967-021-03001-2

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