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Genome-wide identification of m6A-associated single nucleotide polymorphisms in complex diseases of nervous system.

Neuroscience letters - 20 Nov 2023

Guo Fei, Kang Jingxuan, Xu Jing, Wei Siyu, Tao Junxian, Dong Yu, Ma Yingnan, Tian Hongsheng, Guo Xuying, Bi Shuo, Zhang Chen, Lv Hongchao, Shang Zhenwei, Jiang Yongshuai, Zhang Mingming

Abstract excerpt

N6-methyladenosine (m6A) is one of the most abundant chemical modifications on RNA and can affect the occurrence and development of diseases. Some studies have shown that the expressions of some m6A-related genes are significantly regulated by single nucleotide variants (SNV). However, the function of m6A-associated single nucleotide polymorphisms (m6A-SNP) remains unclear in multiple sclerosis (MS), Alzheimer's...

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PMID: 37827449
DOI: 10.1016/j.neulet.2023.137513

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