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Article

m6A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer.

Theranostics - 1 Jan 2020

Zhao Qijie, Zhao Yueshui, Hu Wei, Zhang Yan, Wu Xu, Lu Jianwei, Li Mingxing, Li Wei, Wu Weiqing, Wang Jianhong, Du Fukuan, Ji Huijiao, Yang Xiao, Xu Zhenyu, Wan Lin, Wen Qinglian, Li Xiang, Cho Chi Hin, Zou Chang, Shen Jing, Xiao Zhangang

Abstract excerpt

Rationale: Methylation at the N6 position of adenosine (m6A) is the most prevalent RNA modification within protein-coding mRNAs in mammals, and it is a reversible modification with various important biological functions. The formation and function of m6A are regulated by methyltransferases (writers), demethylases (erasers), and special binding proteins (readers) as key factors. However, the underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32863943
DOI: 10.7150/thno.42971
PMCID: PMC7449908

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