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Article

Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.

Nature communications - 20 Jan 2021

Ku Zhiqiang, Xie Xuping, Davidson Edgar, Ye Xiaohua, Su Hang, Menachery Vineet D, Li Yize, Yuan Zihao, Zhang Xianwen, Muruato Antonio E, I Escuer Ariadna Grinyo, Tyrell Breanna, Doolan Kyle, Doranz Benjamin J, Wrapp Daniel, Bates Paul F, McLellan Jason S, Weiss Susan R, Zhang Ningyan, Shi Pei-Yong, An Zhiqiang

Abstract excerpt

Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The determinants for selecting antibody combinations and the mechanism that antibody cocktails prevent viral escape remain unclear. We compared the critical residues in the receptor-binding domain (RBD) used by multiple neutralizing antibodies and cocktails and identified a combination of two antibodies CoV2-06 and CoV2-14 for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33473140
DOI: 10.1038/s41467-020-20789-7
PMCID: PMC7817669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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