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Article

Role of autophagy in the maintenance and function of cancer stem cells

1 Jan 2015

Abstract excerpt

Recent advances in experimental technologies and cancer models have made possible to demonstrate that the tumor is a dynamic system comprising heterogeneous populations of cancer cells organized in a hierarchical fashion with cancer stem cells (CSCs) at the apex. CSCs are immature cells characterized by self-renewal property and long-term repopulation potential. CSCs have been causally linked to cancer...

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PMID: 26374531
DOI: 10.1387/ijdb.150082iv

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