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Article

Bushenhuoxue formula attenuates cartilage degeneration in an osteoarthritic mouse model through TGF-β/MMP13 signaling.

Journal of translational medicine - 20 Mar 2018

Wang Ping-Er, Zhang Lei, Ying Jun, Jin Xing, Luo Cheng, Xu Shibing, Dong Rui, Xiao Luwei, Tong Peijian, Jin Hongting

Abstract excerpt

BACKGROUND: Articular cartilage degeneration plays a key role in the pathogenesis of osteoarthritis (OA). Bushenhuoxue formula (BSHXF) has been widely used in the treatment of OA in clinics. However, the molecular mechanisms responsible for the chondroprotective effect of BSHXF remain to be elucidated. The purpose of this study was to explore the effects of BSHXF on OA mice model. METHODS: In this study, we...

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Share to Cartilage, Articular
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drugs, Chinese Herbal

Share to Matrix Metalloproteinase 13

Share to Osteoarthritis

Share to Receptor, Transforming Growth Factor-beta Type II

Share to Smad2 Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 29554973
DOI: 10.1186/s12967-018-1437-3
PMCID: PMC5859632

Genes

MMP13
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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