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Challenges and Considerations on Risk-Reducing Surgery in BRCA1/2 Patients with Advanced Breast Cancer.

Current oncology (Toronto, Ont.) - 14 Jan 2021

Vasconcelos de Matos Leonor, Fernandes Leonor, Louro Pedro, Plácido Ana, Barros Manuel, Vaz Fátima

Abstract excerpt

Cancer survivors harboring inherited pathogenic variants in the breast cancer (BC) susceptibility genes BRCA1 or BRCA2 are at increased risk of ovarian cancer (OC) and also of contralateral BC. For these women, risk-reducing surgery (RRS) may contribute to risk management. However, women with locally advanced or metastatic breast cancer (ABC) were excluded from clinical trials evaluating the benefit of these...

Topics

BRCA1 Protein
Breast Neoplasms
Female
Genes, BRCA1
Genes, BRCA2
Heterozygote
Humans
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33466630
DOI: 10.3390/curroncol28010050
PMCID: PMC7903283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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