Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Factors affecting surgical decision-making in carriers of BRCA1/2 pathogenic variants undergoing risk-reducing surgery at a dedicated hereditary ovarian cancer clinic.

Menopause (New York, N.Y.) - 6 Dec 2021

Jacobson Michelle R, Walker Melissa, Ene Gabrielle E V, Firestone Courtney, Bernardini Marcus Q, Allen Lisa, Huszti Ella, Sobel Mara

Abstract excerpt

OBJECTIVE: Women with germline BRCA1/2 pathogenic variants have a significantly elevated lifetime risk of ovarian and fallopian tube cancer. Bilateral salpingo-oophorectomy (RRSO) is associated with a 90% reduction in the development of tubal and ovarian cancer. At our tertiary hospital, we have a dedicated clinic where women predisposed to hereditary ovarian/tubal cancer receive counseling on reproduction, risk...

Topics

BRCA1 Protein
BRCA2 Protein
Canada
Clinical Decision-Making
Female
Genetic Predisposition to Disease
Heterozygote
Humans
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

Ovariectomy

Retrospective Studies

Salpingectomy

Source

Identifiers

PMID: 34873108
DOI: 10.1097/GME.0000000000001900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Factors affecting surgical decision-making in carriers of BRCA1/2 pathogenic variants undergoing risk-reducing surgery at a dedicated hereditary ovarian cancer clinic.PMID 34873108Read ↗

Exploring the role of a multidisciplinary hereditary gynecologic oncology clinic in epithelial ovarian cancer risk-reducing surgical decision-making practices: A mixed-methods study.Semantic proximity Read ↗

Risk-reducing salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

Clinical characteristics and choices regarding risk-reducing surgery in BRCA mutation carriers.Semantic proximity Read ↗

Different Patterns of Risk Reducing Decisions in Affected or Unaffected BRCA Pathogenic Variant Carriers.Semantic proximity Read ↗

Factors associated with deciding between risk-reducing salpingo-oophorectomy and ovarian cancer screening among high-risk women enrolled in GOG-0199: An NRG Oncology/Gynecologic Oncology Group study.Semantic proximity Read ↗

When to Consider Risk-Reducing Mastectomy in BRCA1/BRCA2 Mutation Carriers with Advanced Stage Ovarian Cancer: a Case Study Illustrating the Genetic Counseling Challenges.Semantic proximity Read ↗

Ovarian cancer risk management in BRCA-mutation carriers: A comparison of six international and national guidelines.Semantic proximity Read ↗

Contemporary risk assessment and risk-reducing strategies for tubo-ovarian cancer in women with BRCA pathogenic variants.Semantic proximity Read ↗

Risk-reduction surgery decisions in high-risk women seen for genetic counseling.Semantic proximity Read ↗

Hereditary Women's Cancer: Management and Risk-Reducing Surgery.Semantic proximity Read ↗

Attitude of BRCA1/2 mutation carriers towards surgical risk reduction for breast, ovarian and uterine cancer: still much to be done.Semantic proximity Read ↗

Ovarian Cancer Risk-Reduction and Screening in BRCA1/2 Mutation Carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.