Article
Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes.
Nature genetics - 1 Jul 2002
Kikuchi Shojiro, Hata Masaki, Fukumoto Kanehisa, Yamane Yukari, Matsui Takeshi, Tamura Atsushi, Yonemura Shigenobu, Yamagishi Hisakazu, Keppler Dietrich, Tsukita Shoichiro, Tsukita Sachiko
Abstract excerpt
The ezrin-radixin-moesin (ERM) family of proteins crosslink actin filaments and integral membrane proteins. Radixin (encoded by Rdx) is the dominant ERM protein in the liver of wildtype mice and is concentrated at bile canalicular membranes (BCMs). Here we show that Rdx(-/-) mice are normal at birth, but their serum concentrations of conjugated bilirubin begin to increase gradually around 4 weeks, and they show...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.