Article
The Neisseria type 2 IgA1 protease cleaves LAMP1 and promotes survival of bacteria within epithelial cells.
Molecular microbiology - 1 Jun 1997
Lin L, Ayala P, Larson J, Mulks M, Fukuda M, Carlsson S R, Enns C, So M
Abstract excerpt
Infection of human epithelial cells by Neisseria meningitidis (MC) and Neisseria gonorrhoeae (GC) increases the rate of degradation of LAMP1, a major integral membrane glycoprotein of late endosomes and lysosomes. Several lines of evidence indicate that the neisserial IgA1 protease is directly re...
Topics
- Animals
- Antigens, CD
- Cell Line
- Epithelial Cells
- Epithelium
- Humans
- Lysosomal-Associated Membrane Protein 1
- Lysosomal Membrane Proteins
- Membrane Glycoproteins
- Mutation
- Neisseria meningitidis
- Rabbits