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Article

In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4.

Investigative ophthalmology & visual science - 25 Apr 2014

Mandal Nawajes A, Tran Julie-Thu A, Zheng Lixin, Wilkerson Joseph L, Brush Richard S, McRae Joel, Agbaga Martin-Paul, Zhang Kang, Petrukhin Konstantin, Ayyagari Radha, Anderson Robert E

Abstract excerpt

PURPOSE: Mutations in the elongation of very long chain fatty acids 4 (ELOVL4) gene cause human Stargardt's macular dystrophy 3 (STGD3), a juvenile onset dominant form of macular degeneration. To understand the role of the ELOVL4 protein in retinal function, several mouse models have been developed by using transgenic (TG), knock-in (Elovl4(+/mut)), and knockout (Elovl4(+/-)) approaches. Here we analyzed...

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Identifiers

PMID: 24644051
DOI: 10.1167/iovs.13-13198
PMCID: PMC4001787

Genes

ELOVL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4.PMID 24644051Read ↗

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