Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elovl2 Is Required for Robust Visual Function in Zebrafish.

Cells - 2 Dec 2020

Dasyani Manish, Gao Fangyuan, Xu Qianlan, Van Fossan Donald, Zhang Ellis, F M Pinto Antonio, Saghatelian Alan, Skowronska-Krawczyk Dorota, Chao Daniel L

Abstract excerpt

Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) play critical roles in membrane stability and cell signaling within the retina. ELOVL2 (Elongation of Very Long Chain Fatty Acids-Like 2), an elongase involved in the synthesis of long chain polyunsaturated fatty acids (LC-PUFAs), has recently been implicated in regulating aging in the mammalian retina. In this work, we characterize the expression and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Docosahexaenoic Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Acids, Unsaturated

Share to Lipidomics

Share to Neuroglia

Share to Retina

Share to Vision, Ocular

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33276584
DOI: 10.3390/cells9122583
PMCID: PMC7761535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elovl2 Is Required for Robust Visual Function in Zebrafish.PMID 33276584Read ↗

Polyunsaturated Fatty Acid - mediated Cellular Rejuvenation for Reversing Age-related Vision DeclineSemantic proximity Read ↗

Current Progress in Deciphering Importance of VLC-PUFA in the Retina.Semantic proximity Read ↗

Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration.Semantic proximity Read ↗

The Lipid Elongation Enzyme ELOVL2 is a molecular regulator of aging in the retinaSemantic proximity Read ↗

ELOVL2: Not just a biomarker of agingSemantic proximity Read ↗

Physiological effects of inactivation and the roles of Elovl3/ELOVL3 in maintaining ocular homeostasis.Semantic proximity Read ↗

The Elovl4 Spinocerebellar Ataxia-34 Mutation 736T>G (p.W246G) Impairs Retinal Function in the Absence of Photoreceptor Degeneration.Semantic proximity Read ↗

Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient miceSemantic proximity Read ↗

In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4.Semantic proximity Read ↗

Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease.Semantic proximity Read ↗

Examination of VLC-PUFA-deficient photoreceptor terminals.Semantic proximity Read ↗

Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.