Article

Altered blood cell traits underlie a major genetic locus of severe COVID-19

2020-09-10

Abstract excerpt

<h4>Purpose</h4> The genetic locus 3p21.31 has been associated with severe coronavirus disease 2019 (COVID-19), but the underlying pathophysiological mechanism is unknown. <h4>Methods</h4> To identify intermediate traits of the COVID-19 risk variant, we performed a phenome-wide association study (PheWAS) with 923 phenotypes in 310,999 European individuals from UK Biobank. For candidate target genes, we examined as...

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Literature Corpus work: 31655807-3d3e-5286-8509-355cd9256376
DOI: 10.1101/2020.09.09.20191700

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