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Article

Altered Blood Cell Traits Underlie a Major Genetic Locus of Severe COVID-19.

The journals of gerontology. Series A, Biological sciences and medical sciences - 13 Jul 2021

Zhou Jingqi, Sun Yitang, Huang Weishan, Ye Kaixiong

Abstract excerpt

BACKGROUND: The genetic locus 3p21.31 has been associated with severe coronavirus disease 2019 (COVID-19), but the underlying pathophysiological mechanism is unknown. METHODS: To identify intermediate traits associated with the 3p21.31 locus, we first performed a phenome-wide association study (PheWAS) with 923 phenotypes in 310 999 European individuals from the UK Biobank. For genes potentially regulated by the...

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Identifiers

PMID: 33530099
DOI: 10.1093/gerona/glab035
PMCID: PMC7929197

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