Structural basis of the PE–PPE protein interaction in Mycobacterium tuberculosis

Abstract excerpt

Mycobacterium tuberculosis ( Mtb ), the causative agent of tuberculosis, has developed multiple strategies to adapt to the human host. The five type VII secretion systems, ESX-1–5, direct the export of many virulence-promoting protein effectors across the complex mycobacterial cell wall. One class of ESX substrates is the PE–PPE family of proteins, which is unique to mycobacteria and essential for infection,...

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