Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer’s Disease

3 Feb 2019

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a major public health concern, and there is an urgent need to better understand its complex biology and develop effective therapies. AD progression can be tracked in patients through validated imaging and spinal fluid biomarkers of pathology and neuronal loss. We still, however, lack a coherent quantitative model that explains how these biomarkers interact and evolve over...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Dementia and Cognitive Impairment Research
Share to Health, Environment, Cognitive Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30863455
DOI: 10.1155/2019/6216530

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer’s DiseasePMID 30863455Read ↗

Computational Risk Stratification of Preclinical Alzheimer’s in Younger AdultsSemantic proximity Read ↗

An improved model for disease progression in patients from the Alzheimer's disease neuroimaging initiative.Semantic proximity Read ↗

Data-driven models of dominantly-inherited Alzheimer’s disease progressionSemantic proximity Read ↗

Biomarker Modeling of Alzheimer’s DiseaseSemantic proximity Read ↗

Data-driven models of dominantly-inherited Alzheimer’s disease progressionSemantic proximity Read ↗

Staging biomarkers in preclinical autosomal dominant Alzheimer's disease by estimated years to symptom onsetSemantic proximity Read ↗

A data-driven disease progression model of fluid biomarkers in genetic frontotemporal dementia.Semantic proximity Read ↗

Longitudinal Cognitive and Biomarker Measurements Support a Unidirectional Pathway in Alzheimer’s Disease PathophysiologySemantic proximity Read ↗

Multi-method investigation of factors influencing amyloid onset and impairment in three cohortsSemantic proximity Read ↗

Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia.Semantic proximity Read ↗

Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer’s Disease using PET and Plasma BiomarkersSemantic proximity Read ↗

Quantifying natural amyloid plaque accumulation in the continuum of Alzheimer’s disease using ADNISemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.