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Article

Presenilin 1 mutation likely contributes to U1 small nuclear RNA dysregulation and Alzheimer's disease-like symptoms.

Neurobiology of aging - 1 Apr 2021

Cheng Zhi, Shang Yingchun, Xu Xinxin, Dong Zhiqiang, Zhang Yongwang, Du Zhanqiang, Lu Xinyi, Zhang Tao

Abstract excerpt

Previous studies showed that U1 small nuclear RNA (snRNA) was selectively enriched in the brain of individuals with familial Alzheimer's disease (AD), resulting in widespread changes in RNA splicing. Our study further reported that presenilin-1 (PSEN1) induced an increase in U1 snRNA expression, accompanied by changed amyloid precursor protein expression, β-amyloid level, and cell death in SH-SY5Y cells. However,...

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PMID: 33450722
DOI: 10.1016/j.neurobiolaging.2020.12.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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