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TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates <i>SMN</i> -dependent neurological phenotypes in vivo

2020-10-27

Abstract excerpt

<h4>ABSTRACT</h4> Trimethylguanosine synthase 1 (TGS1) is a highly conserved enzyme that converts the 5’ mono-methylguanosine cap of snRNAs to a trimethylguanosine cap. Here, we show that loss of TGS1 in C. elegans, D. melanogaster and D. rerio results in neurological phenotypes similar to those caused by Survival Motor Neuron (SMN) deficiency. Importantly, expression of human TGS1 ameliorates the SMN -depende...

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Literature Corpus work
bc9bebd1-de23-5831-ac0a-412974eda691
DOI
10.1101/2020.10.27.356782
Open publication

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TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates <i>SMN</i> -dependent neurological phenotypes in vivoDOI 10.1101/2020.10.27.356782
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