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Article

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21.

Molecular neurodegeneration - 28 Apr 2014

Hales Chadwick M, Seyfried Nicholas T, Dammer Eric B, Duong Duc, Yi Hong, Gearing Marla, Troncoso Juan C, Mufson Elliott J, Thambisetty Madhav, Levey Allan I, Lah James J

Abstract excerpt

BACKGROUND: We recently identified U1 small nuclear ribonucleoprotein (snRNP) tangle-like aggregates and RNA splicing abnormalities in sporadic Alzheimer's disease (AD). However little is known about snRNP biology in early onset AD due to autosomal dominant genetic mutations or trisomy 21 in Down syndrome. Therefore we investigated snRNP biochemical and pathologic features in these disorders. FINDINGS: We...

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Identifiers

PMID: 24773620
DOI: 10.1186/1750-1326-9-15
PMCID: PMC4022210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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