Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMA-10 Is a Non-Canonical Member of the TGF-β Sma/Mab Pathway and Immunity Regulator via the DAF-2 Insulin Receptor in Caenorhabditis elegans.

International journal of molecular sciences - 11 Jan 2021

de Lucas María Pilar, Jiménez Marta, Sánchez-Pavón Paloma, Sáez Alberto G, Lozano Encarnación

Abstract excerpt

Transforming growth factor β (TGF-β) signalling pathways are highly conserved across metazoa and play essential roles not only during development but also in adult tissue maintenance. Alterations of these pathways usually result in a plethora of pathologies. In the nematode Caenorhabditis elegans, the TGF-β Sma/Mab (small/male abnormal) pathway regulates various worm phenotypes such as body size, immune response,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Transforming Growth Factor beta
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Immunity, Innate

Share to Immunomodulation

Share to Longevity

Share to Loss of Function Mutation

Share to Receptor, Insulin

Source

Open in PubMed Open full text

Identifiers

PMID: 33440633
DOI: 10.3390/ijms22020638
PMCID: PMC7827673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMA-10 Is a Non-Canonical Member of the TGF-β Sma/Mab Pathway and Immunity Regulator via the DAF-2 Insulin Receptor in Caenorhabditis elegans.PMID 33440633Read ↗

Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.Semantic proximity Read ↗

The expression of TGFbeta signal transducers in the hypodermis regulates body size in C. elegans.Semantic proximity Read ↗

BMP signaling to pharyngeal muscle in the <i>C. elegans</i> response to a bacterial pathogen regulates anti-microbial peptide expression and pharyngeal pumpingSemantic proximity Read ↗

TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging.Semantic proximity Read ↗

Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.Semantic proximity Read ↗

C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation.Semantic proximity Read ↗

lon-1 regulates Caenorhabditis elegans body size downstream of the dbl-1 TGF beta signaling pathway.Semantic proximity Read ↗

Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling.Semantic proximity Read ↗

miR-58 family and TGF-β pathways regulate each other in Caenorhabditis elegans.Semantic proximity Read ↗

SMA-3 smad has specific and critical functions in DBL-1/SMA-6 TGFbeta-related signaling.Semantic proximity Read ↗

Mutants carrying two sma mutations are super small in the nematode C. elegans.Semantic proximity Read ↗

C. elegans ADAMTS ADT-2 regulates body size by modulating TGFβ signaling and cuticle collagen organization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.