Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Cardiac Fibrosis in Young Adults With a Homozygous Frameshift Variant in SERPINE1

14 Jan 2021

Abstract excerpt

Importance: Cardiac fibrosis is exceedingly rare in young adults. Identification of genetic variants that cause early-onset cardiomyopathy may inform novel biological pathways. Experimental models and a single case report have linked genetic deficiency of plasminogen activator inhibitor-1 (PAI-1), a downstream target of cardiac transforming growth factor β, with cardiac fibrosis. Objective: To perform detailed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Fibrosis and Remodeling
Share to Cardiomyopathy and Myosin Studies
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33439236
DOI: 10.1001/jamacardio.2020.6909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Cardiac Fibrosis in Young Adults With a Homozygous Frameshift Variant in SERPINE1PMID 33439236Read ↗

Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause MortalitySemantic proximity Read ↗

Early atrial remodelling drives arrhythmia in Fabry DiseaseSemantic proximity Read ↗

Family screening for hypertrophic cardiomyopathy: Initial cardiologic assessment, and long-term follow-up of genotype-positive phenotype-negative individuals.Semantic proximity Read ↗

Primary Myocardial Fibrosis as an Alternative Phenotype Pathway of Inherited Cardiac Structural Disorders.Semantic proximity Read ↗

Phospholamban cardiomyopathy: a Canadian perspective on a unique populationSemantic proximity Read ↗

Association of Rare Genetic Variants and Early-Onset Atrial Fibrillation in Ethnic Minority Individuals.Semantic proximity Read ↗

Differences in Cardiac Mechanics among Genetically At-Risk First-Degree Relatives: The DCM Precision Medicine StudySemantic proximity Read ↗

Two diseases presenting only as cardiac hypertrophy: differences between the late-onset Fabry disease cardiac variant and hypertrophic cardiomyopathy.Semantic proximity Read ↗

Gene-Gene Interactions Between A<i>LMNA</i>Variant and Common Polymorphisms Drive Early-Onset Atrial FibrillationSemantic proximity Read ↗

Age-Related Penetrance of Phospholamban p.Arg14del CardiomyopathySemantic proximity Read ↗

Phenotypic characterization of people at risk of atrial fibrillation: protocol for the FIND-AF longitudinal cohort study.Semantic proximity Read ↗

Meta-analysis of the role of cardiac magnetic resonance in laminopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.