Article
Primary Myocardial Fibrosis as an Alternative Phenotype Pathway of Inherited Cardiac Structural Disorders.
Circulation - 19 Jun 2018
Junttila M Juhani, Holmström Lauri, Pylkäs Katri, Mantere Tuomo, Kaikkonen Kari, Porvari Katja, Kortelainen Marja-Leena, Pakanen Lasse, Kerkelä Risto, Myerburg Robert J, Huikuri Heikki V
Abstract excerpt
BACKGROUND: Myocardial fibrosis is a common postmortem finding among young individuals with sudden cardiac death. Because there is no known single cause, we tested the hypothesis that some cases of myocardial fibrosis in the absence of identifiable causes (primary myocardial fibrosis [PMF]) are associated with genetic variants. METHODS: Tissue was obtained at autopsy from 4031 consecutive individuals with sudden...
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