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Article

Structure and proposed mechanism for the pH-sensing Helicobacter pylori chemoreceptor TlpB.

Structure (London, England : 1993) - 3 Jul 2012

Goers Sweeney Emily, Henderson J Nathan, Goers John, Wreden Christopher, Hicks Kevin G, Foster Jeneva K, Parthasarathy Raghuveer, Remington S James, Guillemin Karen

Abstract excerpt

pH sensing is crucial for survival of most organisms, yet the molecular basis of such sensing is poorly understood. Here, we present an atomic resolution structure of the periplasmic portion of the acid-sensing chemoreceptor, TlpB, from the gastric pathogen Helicobacter pylori. The structure reveals a universal signaling fold, a PAS domain, with a molecule of urea bound with high affinity. Through biophysical,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22705207
DOI: 10.1016/j.str.2012.04.021
PMCID: PMC3392440

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