Article

Structural insights into how metallochaperones UreE and UreG interact to deliver a toxic metal to urease

2025-12-08

Abstract excerpt

Maturation of urease, a virulence factor for Helicobacter pylori infection, requires the delivery of nickel ions to the metalloenzyme. To avoid cytotoxicity, nickel ions are transferred within protein complexes of metallochaperones to ensure that the toxic metal do not escape into the cytoplasm. In the urease maturation pathway, metallochaperone UreG receives its nickel ions by forming a 2:2 complex with another...

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Literature Corpus work: 3915ea3a-ea89-5722-a0ad-5ee67962217c
DOI: 10.64898/2025.12.08.692910

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Structural insights into how metallochaperones UreE and UreG interact to deliver a toxic metal to ureaseDOI 10.64898/2025.12.08.692910Read

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