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Article

Genetic variants in microRNA machinery genes are associated [corrected] with idiopathic recurrent pregnancy loss risk.

PloS one - 1 Jan 2014

Jung Yong Wook, Jeon Young Joo, Rah HyungChul, Kim Ji Hyang, Shin Ji Eun, Choi Dong Hee, Cha Sun Hee, Kim Nam Keun

Abstract excerpt

OBJECTIVE: Key molecules involved in microRNA (miRNA) biogenesis, such as DROSHA, XPO5, and DICER, have been identified in trophoblast cells, confirming that the miRNA biogenesis pathway is active in human placenta. In addition, miRNAs regulate uterine gene expression associated with inflammatory responses during the peri-implantation period and participate in maternal-fetal immune tolerance. The purpose of this...

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Topics

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Share to Pregnancy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epistasis, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 24769857
DOI: 10.1371/journal.pone.0095803
PMCID: PMC4000197

Genes

RAN
DROSHA
XPO5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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