Article
Protective role of IL33 signaling in negative pregnancy outcomes associated with lipopolysaccharide exposure.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2021
Kozai Keisuke, Iqbal Khursheed, Moreno-Irusta Ayelen, Scott Regan L, Simon Mikaela E, Dhakal Pramod, Fields Patrick E, Soares Michael J
Abstract excerpt
Interleukin 33 (IL33) signaling has been implicated in the establishment and maintenance of pregnancy and in pregnancy disorders. The goal of this project was to evaluate the role of IL33 signaling in rat pregnancy. The rat possesses hemochorial placentation with deep intrauterine trophoblast invasion; features also characteristic of human placentation. We generated and characterized a germline mutant rat model...
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