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Article

Prenatal Lipopolysaccharides Exposure Induces Transgenerational Inheritance of Hypertension

25 Aug 2022

Abstract excerpt

Background: Adverse environmental exposure during the prenatal period can lead to diseases in the offspring, including hypertension. Whether or not the hypertensive phenotype can be transgenerationally transmitted is not known. Methods: Pregnant Sprague Dawley rats were intraperitoneally injected with lipopolysaccharide (LPS) on gestation days 6, 8, 10, and 12 to generate the prenatal LPS exposure model. Blood...

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PMID: 36004643
DOI: 10.1161/circulationaha.122.059891

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